No. Even though many branch locations are open on Saturday (and a few on Sunday), the Federal Reserve Banks are closed. When a branch collects a deposit from you on a Saturday, and you are depositing checks, those checks are held by the bank until the following Monday. Then, they get processed through the Federal Reserve system. That is why many weekend deposits are held (funds unavailable) until at least Monday at midnight.
If you have checks to enter on Saturday or Sunday, please go ahead and do so. There is no reason to wait. We will process them to your bank on Monday*.
*Checks will not be processed on Federal Bank Holidays.